50 years of life-changing therapies

On November 12 1975, the first allogeneic bone marrow transplantation in Sweden was performed at Huddinge Hospital, here in Flemingsberg. From nuclear catastrophe the foundations of bone marrow transplantation had emerged, and with it, the birth of modern stem cell therapy — the same principles that today underpin cell and gene therapies and CAR-T treatments.

On November 28th the 50 years passed was celebrated – and 50 years of CAST (Cell Therapy and Allogeneic Stem Cell Transplantation). The unit that, under the leadership of Professors Gösta Gahrton and Carl-Gustav Groth, carried out the historic transplantation, and has since tirelessly worked to develop new therapies, and save lives.

In honor of that a scientific symposium was held in Birkeaulan at Karolinska University Hospital. Led by Professors Stephan Mielke and Mattias Carlsten, leading experts from Sweden and abroad gathered to highlight how innovation in cell and gene therapy can be translated from research to patients. Through lectures and panel discussions, both CAST’s mission and development, as well as global perspectives on advanced treatments, where showcased. The program also provided insight into ongoing research and future possibilities.

The symposium and celebration not only highlighted ongoing research and future opportunities, but also showed how CAST’s five decades of innovation have contributed to shaping today’s advanced treatments and a unique research environment here in Flemingsberg. A reflection of the enormous expertise, courage, and forward-looking spirit among the dedicated staff who work every day to change the lives of thousands of patients. Or as Christophe Pedroletti, CEO of Karolinska Universitetssjukhuset expressed it so well:

“A long carried and clear vision – to one day cure and relieve what no one else can cure or relieve today. These are big words, but here at CAST, they are not abstract. They take shape in everyday work, in the corridors, in the treatment rooms, in the research labs, and in conversations with families. And we never do this alone – Karolinska University Hospital and Karolinska Institutet are two parts of the same whole. A partnership where care, research and education move in step. Without that close collaboration we would not be standing here today, celebrating half a century of progress.”

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We are most effective and make the greatest impact when we engage our founders and leverage their size, organizations, and influence, and we still strongly believe in this. At the same time, the fact that we have grown as an organization has also made a difference. Today, we are exactly the kind of “two-pizza team” that Amazon founder Jeff Bezos highlights as the most effective. Among other things, we are now running two cluster initiatives and creating a level of engagement, buzz, and content that is noticeable in Flemingsberg and is actually helping to change the area.

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At The Park Novum, you’re met with spacious offices, creative spaces, and a sweeping view over a growing Flemingsberg. Here, entrepreneurs, innovators, and researchers can find a home that not only provides a modern workplace, but also the opportunity to grow together.

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DreamHack Stockholm is not just a festival. It is one of the few occasions in Sweden where audiences, creators, and the industry move within the same space at the same time. In 2025, DreamHack set a new attendance record with over 60,000 visitors at Stockholmsmässan in Älvsjö, with attendees coming from 70 countries. This year, Press Start Game Hub, the game initiative based in Flemingsberg, took part.

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